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One-Pot Three-Component Strategy for Functionalized 2-Aminoimidazoles via Ring Opening of α-Nitro Epoxides

Xiao Guo, Wenteng Chen, Binhui Chen, Wei Huang, Weixing Qi, Guolin Zhang* and Yongping Yu*

*College of Pharmaceutical Science, Zhejiang University, 866 Yuhangtang Road, Zijin Campus, Hangzhou 310058, China, Email:,

X. Guo, W. Chen, B. Chen, W. Huang, W. Qi, G. Zhang, Y. Yu, Org. Lett., 2015, 17, 1157-1159.

DOI: 10.1021/acs.orglett.5b00289 (free Supporting Information)

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A practical three-component domino reaction of α-nitroepoxides and cyanamide with a series of amines enables the synthesis of functionalized 2-aminoimidazole derivatives under mild conditions without any additives.

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One-Pot Three-Component Strategy for Polysubstituted 2-Aminothiazoles via Ring Opening of α-Nitro Epoxides

Y. Zhu, W. Chen, D. Zhao, G. Zhang, Y. Yu, Synthesis, 2019, 51, 2023-2029.

Key Words

Imidazoles, Multicomponent Reactions

ID: J54-Y2015