Copper-Catalyzed One-Pot Synthesis of α-Ketoamides from 1-Arylethanols
Nidhi Sharma, Surya Srinivas Kotha, Nabajit Lahiri, Govindasamy Sekar*
*Department of Chemistry, Indian Institute of Technology Madras, Chennai, Tamil Nadu 600 036, India, Email: gsekariitm.ac.in
N. Sharma, S. S. Kotha, N. Lahiri, G. Sekar, Synthesis, 2015, 47, 726-736.
DOI: 10.1055/s-0034-1379975 (free Supporting Information)
A copper-catalyzed one-pot strategy for the synthesis of α-ketoamides from 1-arylethanols is highly efficient and delivers product in very good yields via alcohol oxidation, sp3 C-H oxidation, and oxidative amidation.
see article for more examples