Copper-Catalyzed One-Pot Synthesis of α-Ketoamides from 1-Arylethanols

Nidhi Sharma, Surya Srinivas Kotha, Nabajit Lahiri, Govindasamy Sekar*

*Department of Chemistry, Indian Institute of Technology Madras, Chennai, Tamil Nadu 600 036, India, Email: gsekariitm.ac.in

N. Sharma, S. S. Kotha, N. Lahiri, G. Sekar, Synthesis, 2015, 47, 726-736.

DOI: 10.1055/s-0034-1379975

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Abstract

A copper-catalyzed one-pot strategy for the synthesis of α-ketoamides from 1-arylethanols is highly efficient and delivers product in very good yields via alcohol oxidation, sp³ C-H oxidation, and oxidative amidation.

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Key Words

copper catalyst, one-pot synthesis, oxidative amidation, α-ketoamides, 1-arylethanols, TBHP, oxygen

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ID: J66-Y2015