Enantioselective Ruthenium-Catalyzed Carbonyl Allylation via Alkyne-Alcohol C-C Bond-Forming Transfer Hydrogenation: Allene Hydrometalation vs Oxidative Coupling
Tao Liang, Khoa D. Nguyen, Wandi Zhang and Michael J. Krische*
*Department of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States, Email: mkrischemail.utexas.edu
T. Liang, K. D. Ngyuen, W. Zhang, M. J. Krische, J. Am. Chem. Soc., 2015, 137, 3161-3164.
DOI: 10.1021/jacs.5b00747 (free Supporting Information)
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Chiral ruthenium(II) complexes catalyze a highly regio-, diastereo-, and enantioselective reaction of alkynes with primary alcohols to form homoallylic alcohols. In this enantioselective carbonyl allylation, alkynes serve as allylmetal equivalents.
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