Organic Chemistry Portal



Catalyst-Free and Metal-Free Electrophilic Bromoamidation of Unactivated Olefins Using the N-Bromosuccinimide/Sulfonamide Protocol

Wesley Zongrong Yu, Feng Chen, Yi An Cheng and Ying-Yeung Yeung*

*3 Science Drive 3, Department of Chemistry, National University of Singapore, Singapore 117543, Singapore, Email:

W. Z. Yu, F. Chen, Y. A. Cheng, Y.-Y. Yeung, J. Org. Chem., 2015, 80, 2815-2821.

DOI: 10.1021/jo502416r


In an efficient, catalyst-free, and metal-free bromoamidation of unactivated olefins, 4-(trifluoromethyl)benzenesulfonamide and N-bromosuccinimide were used as the nitrogen and halogen sources, respectively. The methodology is applicable to both cyclic and aliphatic olefins.

see article for more examples

Key Words

bromination, sulfonamides, NBS

ID: J42-Y2015