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Copper-Catalyzed Direct Amination of Benzoxazoles Using Primary Amines as Nitrogen Sources

Jian Gu, Chun Cai*

*Chemical Engineering College, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, P. R. of China, Email:

J. Gu, C. Cai, Synlett, 2015, 26, 639-642.

DOI: 10.1055/s-0034-1379886

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Copper-catalyzed C-H bond activation enables a facile, efficient, and simple protocol for direct oxidative C-H amination of benzoxazoles with primary amines using tert-butyl peroxide (TBP) as oxidant under air. Various substituted aminobenzoxazoles were synthesized with very good yields.

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Key Words

C-H activation, amination, copper catalysis, benzoxazoles, di-tert-butyl peroxide

ID: J60-Y2015