Cyclopentanone as a Cation-Stabilizing Electron-Pair Donor in the Calcium-Catalyzed Intermolecular Carbohydroxylation of Alkynes
Tobias Stopka and Meike Niggemann*
*Institute of Organic Chemistry, RWTH Aachen University,
52074 Aachen, Germany, Email: niggemann
oc.rwth-aachen.de
T. Stopka, M. Niggemann, Org. Lett., 2015, 17, 1437-1440.
DOI: 10.1021/acs.orglett.5b00312
Abstract
Cyclopentanone as an electron pair donor proved highly efficient for the stabilization of allyl and vinyl cations in combination with a calcium-based catalyst system. The system enabled a transition-metal-free intermolecular carbohydroxylation of alkynes with allyl and propargyl alcohols.
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Key Words
allylations, benzylations, hydrations
ID: J54-Y2015
