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Silver-Catalyzed Double-Decarboxylative Cross-Coupling of α-Keto Acids with Cinnamic Acids in Water: A Strategy for the Preparation of Chalcones

Ning Zhang, Daoshan Yang*, Wei Wei, Li Yuan, Fafa Nie, Laijin Tian and Hua Wang*

*School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, Shandong P. R. China, Email:,

N. Zhang, D. Yang, W. Wei, L. Yuan, F. Nie, L. Tian, H. Wang, J. Org. Chem., 2015, 80, 3258-3263.

DOI: 10.1021/jo502642n

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A silver-catalyzed double-decarboxylative protocol enables an efficient and pratical construction of chalcone derivatives via cascade coupling of substituted α-keto acids with cinnamic acids under mild and environmentally benign aqueous conditions.

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Key Words

enones, sodium peroxydisulfate, green chemistry

ID: J42-Y2015