Palladium-Catalyzed, Ring-Forming Aromatic C-H Alkylations with Unactivated Alkyl Halides
Alexander R. O. Venning, Patrick T. Bohan and Erik J. Alexanian*
*Department of Chemistry, The University of North Carolina at
Chapel Hill, Chapel Hill, North Carolina 27599, United States, Email: eja
email.unc.edu
A. R. O. Venning, P. T. Bohan, E. J. Alexanian, J. Am. Chem. Soc., 2015, 137, 3731-3734.
DOI: 10.1021/jacs.5b01365
see article for more reactions
Abstract
An intramolecular, Pd-catalyzed C-H alkylation of arenes and heteroarenes is successful with various unactivated primary and secondary alkyl halides, including those with β-hydrogens. The mild, catalytic reaction conditions are highly functional group tolerant and facilitate access to a broad range of synthetically and medicinally interesting carbocyclic and heterocyclic systems.
see article for more examples
Key Words
benzocyclohexenes, indanes, indolines
ID: J48-Y2015
