Organic Chemistry Portal



Successively Recycle Waste as Catalyst: A One-Pot Wittig/1,4-Reduction/Paal-Knorr Sequence for Modular Synthesis of Substituted Furans

Long Chen, Yi Du, Xing-Ping Zeng, Tao-Da Shi, Feng Zhou and Jian Zhou*

*Shanghai Key Laboratory of Green Chemistry and Chemical Process, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, P. R. China, Email:

L. Chen, Y. Du, X.-P. Zeng, T.-D. Shi, F. Zhou, J. Zhou, Org. Lett., 2015, 17, 1557-1560.

DOI: 10.1021/acs.orglett.5b00442 (free Supporting Information)

see article for more reactions


A one-pot tandem Wittig/conjugate reduction/Paal-Knorr reaction enables the synthesis of di- or trisubstituted furans and demonstrates the possibility of successively recycling waste from upstream steps to catalyze downstream reactions.

see article for more examples

Key Words


ID: J54-Y2015