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Cooperation of a Reductant and an Oxidant in One Pot To Synthesize Amides from Nitroarenes and Aldehydes

Guozhu Sheng, Xia Wu, Xiuhua Cai, Wei Zhang*

*College of Chemistry and Pharmaceutical Science, Qingdao Agricultural University No. 700, The Great Wall Road, Chengyang District, Qingdao City, Shandong Province, P. R. of China, Email:

G. Sheng, X. Wu, X. Cai, W. Zhang, Synthesis, 2015, 47, 949-954.

DOI: 10.1055/s-0034-1380111


The combination of zinc powder as reductant and sodium chlorate as oxidant was used to provide an environmentally friendly, effective, and convenient method for the synthesis of aromatic amides in good yields from nitroarenes and aldehydes in a green solvent under atmospheric conditions. Reductants and oxidants with opposing properties can be used together without any adverse effects. In addition, a cooperation seems to improve the yield.

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Key Words

nitroarenes, reduction of nitro compounds, oxidative amidation, aldehydes, amides, zinc, sodium chlorate, synthetic methods, one pot

ID: J66-Y2015