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Transition-Metal-Free Hydration of Nitriles Using Potassium tert-Butoxide under Anhydrous Conditions

Ganesh Chandra Midya, Ajoy Kapat, Subhadip Maiti and Jyotirmayee Dash*

*Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, India, Email:

G. C. Midya, A. Kapat, S. Maiti, J. Dash, J. Org. Chem., 2015, 80, 4148-4151.

DOI: 10.1021/jo502752u


Potassium tert-butoxide acts as a nucleophilic oxygen source during the hydration of a broad range of nitriles to give the corresponding amides under mild, anhydrous conditions. The easily scalable reaction provides an efficient and economically affordable synthetic route to amides in excellent yields without any transition-metal catalyst or any special experimental setup.

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ID: J42-Y2015