Organic Chemistry Portal



Chemoselective Formation of Unsymmetrically Substituted Ethers from Catalytic Reductive Coupling of Aldehydes and Ketones with Alcohols in Aqueous Solution

Nishantha Kalutharage and Chae S. Yi*

*Department of Chemistry, Marquette University, Milwaukee, Wisconsin 53201-1881 United States, Email:

N. Kalutharage, C. S. Yi, Org. Lett., 2015, 17, 1778-1781.

DOI: 10.1021/acs.orglett.5b00553


A well-defined cationic Ru-H complex catalyzes reductive etherification of aldehydes and ketones with alcohols using water as the solvent and cheaply available molecular hydrogen as the reducing agent to afford unsymmetrical ethers in a highly chemoselective manner.

see article for more examples

Key Words

reductive etherification, hydrogen

ID: J54-Y2015