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[2.2]Paracyclophane-Derived Monodentate Phosphoramidite Ligands for Copper-Catalyzed Asymmetric Conjugate Addition of Diethylzinc to Substituted Chalcones

Lei Han, Yang Lei, Ping Xing, Xiao-Long Zhao and Biao Jiang*

*Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China, Email:

L. Han, Y. Lei, P. Xing, X.-L. Zhao, B. Jiang, J. Org. Chem., 2015, 80, 3752-3757.

DOI: 10.1021/jo502715f (free Supporting Information)

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The use of [2.2]paracyclophane-derived monodentate phosphoramidite ligands enabled a copper-catalyzed asymmetric conjugate addition of diethylzinc to chalcones in excellent yield and enantioselectivity with low catalyst loading.

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Key Words

conjugate addition

ID: J42-Y2015