Highly Diastereo- and Enantioselective CuH-Catalyzed Synthesis of 2,3-Disubstituted Indolines
Erhad Ascic and Stephen L. Buchwald*
*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States, Email: sbuchwalmit.edu
E. Ascic, S. L. Buchwald, J. Am. Chem. Soc., 2015, 137, 4666-4669.
DOI: 10.1021/jacs.5b02316 (free Supporting Information)
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A diastereo- and enantioselective CuH-catalyzed method for the preparation of highly functionalized indolines offers mild reaction conditions and high degree of functional group compatibility. This method is highly valuable for the synthesis various cis-2,3-disubstituted indolines in high yield and enantioselectivity.
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