Palladium Catalyzed Vinyltrifluoromethylation of Aryl Halides through Decarboxylative Cross-Coupling with 2-(Trifluoromethyl)acrylic Acid
Subban Kathiravan and Ian A. Nicholls*
*Bioorganic & Biophysical Chemistry Laboratory, Linnaeus University Centre for Biomaterials Chemistry, Linnaeus University, SE-391 82 Kalmar, Sweden, Email: ian.nichollslnu.se
S. Kathiravan, I. A. Nicholls, Org. Lett., 2015, 17, 1874-1877.
DOI: 10.1021/acs.orglett.5b00551 (free Supporting Information)
An efficient Pd-catalyzed stereoselective vinyltrifluoromethylation of aryl halides, through decarboxylative cross-coupling with 2-(trifluoromethyl)acrylic acid offers ready availability of the starting materials, high level of functional group tolerance, and excellent E/Z selectivity. This protocol is a safe and operationally convenient strategy for an efficient synthesis of vinyltrifluoromethyl derivatives.
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