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Metal-Free Synthesis of Indole via NIS-Mediated Cascade C-N Bond Formation/Aromatization

Yin-Long Li, Jian Li, Ai-Lun Ma, Ya-Nan Huang and Jun Deng*

*School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, People's Republic of China, Email:

Y.-L. Li, J. Li, A.-L. Ma, Y.-N. Huang, J. Deng, J. Org. Chem., 2015, 80, 3841-3851.

DOI: 10.1021/acs.joc.5b00090

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A rapid synthesis of indoles from N-Ts-2-alkenylanilines involves a NIS-mediated cascade C-N bond formation/aromatization. A series of indoles with various functional groups have been synthesized in very good yields under mild conditions without any other additives or catalysts.

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Key Words

indoles, NIS

ID: J42-Y2015