Organic Chemistry Portal



One-Pot Sonogashira Coupling-Cyclization toward Regioselective Synthesis of Benzosultams

Sudarshan Debnath and Shovan Mondal*

*Department of Chemistry, Visva-Bharati University, Santiniketan 731235, India, Email:

S. Debnath, S. Mondal, J. Org. Chem., 2015, 80, 3940-3948.

DOI: 10.1021/acs.joc.5b00274

see article for more reactions


A one-pot method for the Sonogashira coupling and cyclization of 2-bromobenzenesulfonamides and terminal alkynes allows access to various substituted benzosultams regioselectively in excellent yields.

see article for more examples

Key Words

sultams, benzo-fused S-Heterocycles, benzo-fused N-Heterocycles

ID: J42-Y2015