Synthesis of Carbodiimides by I₂/CHP-Mediated Cross-Coupling Reaction of Isocyanides with Amines under Metal-Free Conditions

Tong-Hao Zhu, Shun-Yi Wang*, Yang-Qing Tao and Shun-Jun Ji*

*Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Soochow University, Suzhou 215123, P. R. China, Email: shunyisuda.edu.cn, shunjunsuda.edu.cn

T.-H. Zhu, S.-Y. Wang, Y.-Q. Tao, S.-J. Ji, Org. Lett., 2015, 17, 1974-1977.

DOI: 10.1021/acs.orglett.5b00722

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Abstract

An I₂/CHP-mediated cross-coupling reaction of isocyanides with readily accessible amines gives carbodiimides in good yields. This metal-free strategy for coupling of isocyanides with amines provides an efficient approach for symmetric and unsymmetric functionalized carbodiimide derivative synthesis under mild conditions.

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Key Words

Carbodiimides, cumene hydroperoxide, iodine

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ID: J54-Y2015