Iridium-Catalyzed Single-Step N-Substituted Lactam Synthesis from Lactones and Amines

Kicheol Kim and Soon Hyeok Hong*

*Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul 151-747, Korea, Email: soonhongsnu.ac.kr

K. Kim, S. H. Hong, J. Org. Chem., 2015, 80, 4152-4156.

DOI: 10.1021/acs.joc.5b00101

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Abstract

Ir catalysis achieves a lactam synthesis directly from lactones and amines via aminolysis of lactone, N-alkylation of amine with hydroxyamide, and intramolecular transamidation of aminoamide.

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Key Words

γ-lactams, δ-lactams

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ID: J42-Y2015