Iridium-Catalyzed Single-Step N-Substituted Lactam Synthesis from Lactones and Amines
Kicheol Kim and Soon Hyeok Hong*
*Department of Chemistry, College of Natural Sciences, Seoul
National University, Seoul 151-747, Korea, Email: soonhong
snu.ac.kr
K. Kim, S. H. Hong, J. Org. Chem., 2015, 80, 4152-4156.
Abstract
Ir catalysis achieves a lactam synthesis directly from lactones and amines via aminolysis of lactone, N-alkylation of amine with hydroxyamide, and intramolecular transamidation of aminoamide.
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Key Words
ID: J42-Y2015
