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Decarboxylative Fluorination of Aliphatic Carboxylic Acids via Photoredox Catalysis

Sandrine Ventre, Filip R. Petronijevic and David W. C. MacMillan*

*Merck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States, Email: dmacmillprinceton.edu

S. Ventre, F. R. Petronijevic, D. W. C. MacMillan, J. Am. Chem. Soc., 2015, 137, 5654-5657.

DOI: 10.1021/jacs.5b02244 (free Supporting Information)


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Abstract

Visible light-promoted photoredox catalysis enables a direct conversion of aliphatic carboxylic acids to the corresponding alkyl fluorides. This operationally simple, redox-neutral fluorination method allows the conversion of a broad range of carboxylic acids.

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Key Words

fluorination, Selectfluor


ID: J48-Y2015