Palladium-Catalyzed Asymmetric Addition of Arylboronic Acids to Nitrostyrenes
Qun He, Fang Xie, Guanghong Fu, Mao Quan, Chaoren Shen, Guoqiang Yang*, Ilya D. Gridnev and Wanbin Zhang*
*School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China, Email: gqyangsjtu.edu.cn, wanbinsjtu.edu.cn
Q. He, F. Xie, G. Fu, M. Quan, C. Shen, G. Yang, I. D. Gridnev, W. Zhang, Org. Lett., 2015, 17, 2250-2253.
DOI: 10.1021/acs.orglett.5b00863 (free Supporting Information)
iPr-IsoQuinox as a chiral ligand enables a palladium-catalyzed asymmetric addition of arylboronic acids to nitrostyrene in MeOH as solvent under an air atmosphere providing chiral diarylsubstituted products in high yields with good enantioselectivities. A broad range of substrates can be used.
see article for more examples