Mn-Catalyzed Highly Efficient Aerobic Oxidative Hydroxyazidation of Olefins: A Direct Approach to β-Azido Alcohols
Xiang Sun, Xinyao Li, Song Song, Yuchao Zhu, Yu-Feng Liang and Ning Jiao*
*State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Xue Yuan Rd. 38, Beijing 100191, China, Email: jiaoningbjmu.edu.cn
X. Sun, X. Li, S. Song, Y. Zhu, Y.-F. Liang, N. Jiao, J. Am. Chem. Soc., 2015, 137, 6059-6066.
DOI: 10.1021/jacs.5b02347 (free Supporting Information)
see article for more reactions
In an efficient Mn-catalyzed aerobic oxidative hydroxyazidation of olefins for synthesis of β-azido alcohols, an aerobic oxidative generation of azido radical is a key process. The reaction offers broad substrate scope, the use of an inexpensive Mn-catalyst, high efficiency, easy operation under air, and mild conditions at room temperature.
see article for more examples