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Copper(I)-Catalyzed Asymmetric Pinacolboryl Addition of N-Boc-imines Using a Chiral Sulfoxide-Phosphine Ligand

Ding Wang, Peng Cao, Bing Wang, Tao Jia, Yazhou Lou, Min Wang and Jian Liao*

*Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China, Email: jliaocib.ac.cn

D. Wang, P. Cao, B. Wang, T. Jia, Y. Lou, M. Wang, J. Liao, Org. Lett., 2015, 17, 2420-2423.

DOI: 10.1021/acs.orglett.5b00934



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Abstract

A single chiral sulfoxide-(dialkyl)phosphine (SOP) ligand enables a highly efficient and enantioselective copper(I)-catalyzed pinacolboryl addition to N-Boc-imines providing both enantiomeric isomers of α-amino boronic esters depending on an achiral counteranion switch.

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Key Words

boronates


ID: J54-Y2015