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An Efficient, Mild, Solvent-Free, One-Pot Three-Component Mannich Reaction Catalyzed by (C4H12N2)2[BiCl6]ClH2O

Hongfei Lu*, Runze Wu, Helong Cheng, Shipeng Nie, Yan Tang, Yuhua Gao, Zhibin Luo*

*Jiangsu University of Science and Technology; Jiangsu University, Zhenjiang 212003, P. R. of China, Email:,

H. Lu, R. Wu, H. Cheng, S. Nie, Y. Tang, Y. Gao, Z. Luo, Synthesis, 2015, 47, 1280-1290.

DOI: 10.1055/s-0034-1380278

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An efficient and practical one-pot Mannich reaction of aromatic ketones with aldehydes and amines at room temperature under solvent-free conditions is catalyzed by (C4H12N2)2[BiCl6]ClH2O. The catalyst can be recycled multiple times by simple isolation protocols without compromising the catalytic efficiency.

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Key Words

Mannich Reaction, Multicomponent Reactions, Lewis acids, Mannich bases, amines, catalysis, aldehydes

ID: J66-Y2015