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Synthesis of 1,2,3-Substituted Pyrroles from Propargylamines via a One-Pot Tandem Enyne Cross Metathesis-Cyclization Reaction

Helene Chachignon, Nicoḷ Scalacci, Elena Petricci and Daniele Castagnolo*

*Institute of Pharmaceutical Science, King's College London, Franklin-Wilkins Building, 150 Stamford Street, SE1 9NH, Email:

H. Chachignon, N. Scalacci, E. Petricci, D. Castagnolo, J. Org. Chem., 2015, 80, 5287-5295.

DOI: 10.1021/acs.joc.5b00222 (free Supporting Information)


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Enyne cross metathesis of propargylamines with ethyl vinyl ether provides a series of substituted pyrroles, bearing alkyl, aryl, and heteroaryl substituents under microwave irradiation.

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proposed diene intermediate

Key Words

enyne metathesis, pyrroles, microwave synthesis

ID: J42-Y2015