A Direct Metal-Free Decarboxylative Sulfono Functionalization (DSF) of Cinnamic Acids to α,β-Unsaturated Phenyl Sulfones
Rahul Singh, Bharat Kumar Allam, Neetu Singh, Kumkum Kumari, Satish Kumar Singh and Krishna Nand Singh*
*Department of Chemistry (Centre of Advanced Study), Banaras Hindu University, Varanasi 221005, India, Email: knsinghbhu.ac.in
R. Singh, B. K. Allam, N. Singh, K. Kumari, S. K. Singh, K. N. Singh, Org. Lett., 2015, 17, 2656-2659.
DOI: 10.1021/acs.orglett.5b01037 (free Supporting Information)
see article for more reactions
A metal-free room temperature decarboxylative cross-coupling between cinnamic acids and arylsulfonyl hydrazides provides (E)-vinyl sulfones. A regio- and stereoselective synthesis of 22 derivatives with diverse structural features has been achieved.
see article for more examples