Highly Enantioselective and Anti-Diastereoselective Catalytic Intermolecular Glyoxylate-Ene Reactions: Effect of the Geometrical Isomers of Alkenes
Xiang Zhang, Min Wang, Ran Ding, Yun-He Xu* and Teck-Peng Loh*
*Department of Chemistry, University of Science and
Technology of China, Hefei 230026, China, Email: xyh0709
ustc.edu.cn,
teckpengntu.edu.sg
X. Zhang, M. Wang, R. Ding, Y.-H. Xu, T.-P. Loh, Org. Lett., 2015, 17, 2736-2739.
DOI: 10.1021/acs.orglett.5b01151
see article for more reactions
Abstract
An In(III)-catalyzed intermolecular glyoxylate-ene reaction enables an efficient synthesis of homoallylic alcohols with high enantioselectivities and anti-diastereoselectivities. Only alkene isomers having a proton β-cis to the substituent reacted in this catalytic system.
see article for more examples
Key Words
homoallylic alcohols, Alder-Ene Reaction
ID: J54-Y2015
