Organic Chemistry Portal



Catalyst- and Solvent-Free Rapid Addition of Secondary Phosphine Chalcogenides to Aldehydes: Another Click Chemistry

Nina K. Gusarova, Nina I. Ivanova, Pavel A. Volkov, Kseniya O. Khrapova, Luydmila I. Larina, Vladimir I. Smirnov, Tatyana N. Borodina, Boris A. Trofimov*

*A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, 1 Favorsky Str., 664033 Irkutsk, Russian Federation, Email:

N. K. Gusarova, N. I. Ivanova, P. A. Volkov, K. O. Khrapova, L. I. Larina, V. I. Smirnov, T. N. Borodina, B. A. Trofimov, Synthesis, 2015, 47, 1611-1622.

DOI: 10.1055/s-0034-1380408 (free Supporting Information)

see article for more reactions


An efficient catalyst- and solvent-free addition of secondary phosphine chalcogenides to diverse aldehydes enables an almost quantitative synthesis of tertiary α-hydroxyphosphine chalcogenides under mild conditions (20-52 C, from 10 min to 5 h).

see article for more examples

Key Words

addition, aldehydes, green chemistry, phosphine chalcogenides, phosphine oxides

ID: J66-Y2015