Trifluoromethyl-Substituted Sulfonium Ylide: Rh-Catalyzed Carbenoid Addition to Trifluoromethylthioether
Yafei Liu, Xinxin Shao, Panpan Zhang, Long Lu* and Qilong Shen*
*Key Laboratory of Organofluorine Chemistry, Shanghai
Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu,
Shanghai 200032, China, Email: shenql
mail.sioc.ac.cn, lulongmail.sioc.ac.cn
S. Liu, X. Shao, P. Zhang, L. Lu, Q. Shen, Org. Lett., 2015, 17, 2752-2755.
DOI: 10.1021/acs.orglett.5b01170
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Abstract
A highly efficient Rh-catalyzed carbenoid addition to trifluoromethylthioether enables the formation of a trifluoromethyl-substituted sulfonium ylide. This ylide can act as an electrophilic trifluoromethylation reagent, as demonstrated by trifluoromethylation of β-ketoesters and aryl iodides.
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Copper-Catalyzed Trifluoromethylation of (Hetero)aryl Boronic Acid Pinacol Esters with YlideFluor
J. Liu, Y. Xiao, J. Hao, Q. Shen, Org. Lett., 2023, 25, 1204-1208.
Key Words
ID: J54-Y2015
