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Coproduct Promoted Povarov Reaction: Synthesis of Substituted Quinolines from Methyl Ketones, Arylamines and α-Ketoesters

Qinghe Gao, Shan Liu, Xia Wu, Jingjing Zhang and Anxin Wu*

*Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China, Email: chwuaxmail.ccnu.edu.cn

Q. Gao, S. Liu, X. Wu, J. Zhang, A. Wu, J. Org. Chem., 2015, 80, 5984-5991.

DOI: 10.1021/acs.joc.5b00785 (free Supporting Information)


 

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Abstract

A highly efficient I2-catalyzed Povarov-type reaction of methyl ketones, arylamines, and α-ketoesters provides substituted quinolones in very good yields. The convenient procedure offers good functional group compatibility.

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Key Words

Quinolines


ID: J42-Y2015