Chemoselective Reductive Amination of Carbonyl Compounds for the Synthesis of Tertiary Amines Using SnCl₂·2H₂O/PMHS/MeOH

Onkar S. Nayal, Vinod Bhatt, Sushila Sharma and Neeraj Kumar*

*Natural Product Chemistry and Process Development Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, Himachal Pradesh 176 061, India, Email: neerajihbt.res.in

O. S. Nayal, V. Bhatt, S. Sharma, N. Kumar, J. Org. Chem., 2015, 80, 5912-5918.

DOI: 10.1021/acs.joc.5b00156

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Abstract

Stannous chloride catalyzes a chemoselective reductive amination of various carbonyl compounds with aromatic amines using inexpensive polymethylhydrosiloxane as reducing agent in methanol. The present method is applicable for the synthesis of tertiary and secondary amines.

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Key Words

reductive amination, PMHS

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ID: J42-Y2015