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Synthesis of Multiple-Substituted Pyrroles via Gold(I)-Catalyzed Hydroamination/Cyclization Cascade

Xiangdong Li, Ming Chen, Xin Xie, Ning Sun, Shi Li* and Yuanhong Liu*

*State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, People's Republic of China, Email:,

X. Li, M. Chen, X. Xie, N. Sun, S. Li, Y. Liu, Org. Lett., 2015, 17, 2984-2987.

DOI: 10.1021/acs.orglett.5b01281 (free Supporting Information)

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A gold-catalyzed cascade hydroamination/cyclization reaction of α-amino ketones with alkynes gives substituted pyrroles. The method offers high regioselectivity, wide functional group tolerance, and easily accessible starting materials.

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ID: J54-Y2015