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Indolizine Synthesis via Oxidative Cross-Coupling/Cyclization of Alkenes and 2-(Pyridin-2-yl)acetate Derivatives

Ren-Rong Liu, Jian-Jun Hong, Chuan-Jun Lu, Meng Xu, Jian-Rong Gao and Yi-Xia Jia*

*College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China, Email:

R.-R. Liu, J. J. Hong, C.-J. Lu, M. Xu, J.-R. Gao, Y.-X. Jia, Org. Lett., 2015, 17, 3050-3053.

DOI: 10.1021/acs.orglett.5b01334

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A novel copper/I2-mediated oxidative cross-coupling/cyclization of 2-(pyridin-2-yl)acetate derivatives and simple olefins provides a straightforward and efficient access to 1,3-di- and 1,2,3-trisubstituted indolizines in good yields.

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Key Words

indolizines, iodine

ID: J54-Y2015