Selective Copper-Catalyzed N-Arylation of Lactams with Arylboronic Acids under Base- and Ligand-Free Conditions
Thulasiram Bathini, Vikas Singh Rawat, Bojja Sreedhar*
*Inorganic & Physical Chemistry Division, Indian Institute of Chemical Technology (Council of Scientific & Industrial Research), Hyderabad - 500007, India, Email: sreedharbiict.res.in
T. Bathini, V. S. Rawat, B. Sreedhar, Synlett, 2015, 26, 1348-1351.
An oxidative copper-catalyzed arylation of various ring-size lactams with arylboronic acids gives N-arylated products in good yield without any additional bases, ligands, or additives.
see article for more examples
lactams, γ-lactams, catalysis, copper, cross-coupling, oxidation, TBHP