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Selective Copper-Catalyzed N-Arylation of Lactams with Arylboronic Acids under Base- and Ligand-Free Conditions

Thulasiram Bathini, Vikas Singh Rawat, Bojja Sreedhar*

*Inorganic & Physical Chemistry Division, Indian Institute of Chemical Technology (Council of Scientific & Industrial Research), Hyderabad - 500007, India, Email:

T. Bathini, V. S. Rawat, B. Sreedhar, Synlett, 2015, 26, 1348-1351.

DOI: 10.1055/s-0034-1380741


An oxidative copper-catalyzed arylation of various ring-size lactams with arylboronic acids gives N-arylated products in good yield without any additional bases, ligands, or additives.

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Key Words

lactams, γ-lactams, ε-lactams, catalysis, copper, cross-coupling, oxidation, TBHP

ID: J60-Y2015