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Synthesis of Ethers from Carbonyl Compounds by Reductive Etherification Catalyzed by Iron(III) and Silyl Chloride

Risto Savela, Reko Leino*

*Laboratory of Organic Chemistry, Åbo Akademi University, 20500 Åbo, Finland, Email: reko.leinoabo.fi

R. Savela, R. Leino, Synthesis, 2015, 47, 1749-1760.

DOI: 10.1055/s-0034-1380155 (free Supporting Information)


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Abstract

A simple iron- and silyl chloride catalyzed reductive etherification enables the preparation of symmetrical and nonsymmetrical ethers from various aldehydes and ketones in the presence of triethylsilane as a reducing agent and catalytic amounts of  iron(III) oxo acetate and chloro(trimethyl)silane. The reactions can be carried out at ambient temperatures in ethyl acetate as the solvent.

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Key Words

iron, catalysis, silicon, reductive etherification, aldehydes, ketones, triethylsilane


ID: J66-Y2015