Organic Chemistry Portal



Synthesis of Ethers from Carbonyl Compounds by Reductive Etherification Catalyzed by Iron(III) and Silyl Chloride

Risto Savela, Reko Leino*

*Laboratory of Organic Chemistry, Åbo Akademi University, 20500 Åbo, Finland, Email:

R. Savela, R. Leino, Synthesis, 2015, 47, 1749-1760.

DOI: 10.1055/s-0034-1380155 (free Supporting Information)

see article for more reactions


A simple iron- and silyl chloride catalyzed reductive etherification enables the preparation of symmetrical and nonsymmetrical ethers from various aldehydes and ketones in the presence of triethylsilane as a reducing agent and catalytic amounts of  iron(III) oxo acetate and chloro(trimethyl)silane. The reactions can be carried out at ambient temperatures in ethyl acetate as the solvent.

see article for more examples

Key Words

iron, catalysis, silicon, reductive etherification, aldehydes, ketones, triethylsilane

ID: J66-Y2015