Palladium-Catalyzed Enantioselective Three-Component Synthesis of α-Substituted Amines
Tamara Beisel and Georg Manolikakes*
*Department of Organic Chemistry and Chemical Biology,
Goethe-University Frankfurt, Max-von-Laue-Strasse 7, 60438 Frankfurt am Main,
Germany, Email: g.manolikakes
chemie.uni-frankfurt.de
T. Beisel, G. Manolikakes, Org. Lett., 2015, 17, 3162-3165.
DOI: 10.1021/acs.orglett.5b01502
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Abstract
A palladium-catalyzed, enantioselective three-component reaction of sulfonamides, aldehydes, and arylboronic acids generates a wide array of α-arylamines with high yields and enantioselectivities. Notably, this process tolerates air and moisture and provides an operationally simple approach for the synthesis of chiral α-arylamines.
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A Lewis Acid Palladium(II)-Catalyzed Three-Component Synthesis of α-Substituted Amides
T. Beisel, G. Manolikakes, Org. Lett., 2013, 15, 6046-6049.
Key Words
benzylic amines, sulfonamides, multicomponent reactions
ID: J54-Y2015
