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Palladium-Catalyzed Enantioselective Three-Component Synthesis of α-Substituted Amines

Tamara Beisel and Georg Manolikakes*

*Department of Organic Chemistry and Chemical Biology, Goethe-University Frankfurt, Max-von-Laue-Strasse 7, 60438 Frankfurt am Main, Germany, Email: g.manolikakeschemie.uni-frankfurt.de

T. Beisel, G. Manolikakes, Org. Lett., 2015, 17, 3162-3165.

DOI: 10.1021/acs.orglett.5b01502 (free Supporting Information)


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Abstract

A palladium-catalyzed, enantioselective three-component reaction of sulfonamides, aldehydes, and arylboronic acids generates a wide array of α-arylamines with high yields and enantioselectivities. Notably, this process tolerates  air and moisture and provides an operationally simple approach for the synthesis of chiral α-arylamines.

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A Lewis Acid Palladium(II)-Catalyzed Three-Component Synthesis of α-Substituted Amides

T. Beisel, G. Manolikakes, Org. Lett., 2013, 15, 6046-6049.


Key Words

benzylic amines, sulfonamides, multicomponent reactions


ID: J54-Y2015