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Chloroform as a Carbon Monoxide Precursor: In or Ex Situ Generation of CO for Pd-Catalyzed Aminocarbonylations

Samuel N. Gockel and Kami L. Hull*

*Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, United States, Email: kamihullillinois.edu

S. N. Gockel, K. L. Hull, Org. Lett., 2015, 17, 3236-3239.

DOI: 10.1021/acs.orglett.5b01385

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Abstract

Conditions for the rapid hydrolysis of chloroform to carbon monoxide (CO) in the presence of heterogeneous CsOHˇH2O enable palladium-catalyzed aminocarbonylation of aryl, vinyl, and benzyl halides with a broad range of primary and secondary amines in very good yields.


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Key Words

aminocarbonylation

ID: J54-Y2015