Base-Promoted β-C(sp3)-H Functionalization of Enaminones: An Approach to Polysubstituted Pyridines
Jinhai Shen, Dingding Cai, Changsheng Kuai, Yunqi Liu, Ming'e Wei, Guolin Cheng and Xiuling Cui*
*Institutes of Molecular Medicine and School of Biomedical Sciences, Huaqiao University & Engineering Research Center of Molecular Medicine, Ministry of Education, Xiamen 361021, China, Email: cuixlhqu.edu.cn
J. Shen, D. Cai, C. Kuai, Y. Liu, M. Wei, G. Cheng, X. Cui, J. Org. Chem., 2015, 80, 6584-6589.
DOI: 10.1021/acs.joc.5b00635 (free Supporting Information)
see article for more reactions
A convenient base-promoted reaction of 1-arylethylamines with ynones gives polysubstituted pyridines via direct β-C(sp3)-H functionalization of enaminones under metal-free conditions. This procedure features high regioselectivity, high efficiency, and environmental friendliness. Various polysubstituted pyridines were provided in high yields.
see article for more examples