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Ligand-Free Palladium-Catalyzed Hydroxycarbonylation of Aryl Halides under Ambient Conditions: Synthesis of Aromatic Carboxylic Acids and Aromatic Esters

Wei Han*, Fengli Jin, Qing Zhou

*Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Nanjing 210023, P. R. of China, Email:

W. Han, F. Jin, Q. Zhou, Synthesis, 2015, 47, 1861-1868.

DOI: 10.1055/s-0034-1380497 (free Supporting Information)

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A ligand-free palladium-catalyzed hydroxycarbonylation of aryl halides provides the corresponding aromatic carboxylic acids in high yields with high selectivity at room temperature and atmospheric pressure. The new method is operationally simple and scalable. In addition, aromatic esters were easily synthesized through hydroxycarbonylation followed by a one-pot alkylation with alkyl halides.

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Key Words

aryl halides, carbonylation, carboxylic acids, hydroxycarbonylation, palladium

ID: J66-Y2015