Ligand-Free Palladium-Catalyzed Hydroxycarbonylation of Aryl Halides under Ambient Conditions: Synthesis of Aromatic Carboxylic Acids and Aromatic Esters
Wei Han*, Fengli Jin, Qing Zhou
*Jiangsu Collaborative Innovation Center of Biomedical
Functional Materials, Nanjing 210023, P. R. of China, Email: hanwei
njnu.edu.cn
W. Han, F. Jin, Q. Zhou, Synthesis, 2015, 47, 1861-1868.
DOI: 10.1055/s-0034-1380497
see article for more reactions
Abstract
A ligand-free palladium-catalyzed hydroxycarbonylation of aryl halides provides the corresponding aromatic carboxylic acids in high yields with high selectivity at room temperature and atmospheric pressure. The new method is operationally simple and scalable. In addition, aromatic esters were easily synthesized through hydroxycarbonylation followed by a one-pot alkylation with alkyl halides.
see article for more examples
Key Words
aryl halides, carbonylation, carboxylic acids, hydroxycarbonylation, palladium
ID: J66-Y2015
