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A Simple and Green Procedure for the One-Pot Synthesis of α-Aminophosphonates with Quaternary Ammonium Salts as Efficient and Recyclable Reaction Media

Ya-Qin Yu, Da-Zhen Xu*

*National Pesticide Engineering Research Center (Tianjin), Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, P. R. of China, Email: xudazhennankai.edu.cn

Y.-Q. Yu, D.-Z. Xu, Synthesis, 2015, 47, 1869-1876.

DOI: 10.1055/s-0034-1380523


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Abstract

The use of quaternary ammonium salts, which are environmental friendly, inexpensive, and recyclable enables a simple and highly efficient multicomponent reaction of aldehydes or ketones with amines and diethyl or triethyl phosphite to give the corresponding α-aminophosphonates in excellent yields at room temperature.


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Key Words

Kabachnik-Fields reaction, multicomponent reactions, quaternary ammonium salts, green chemistry, phosphorylations


ID: J66-Y2015