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Iodine Catalyzed Oxidative Synthesis of Quinazolin-4(3H)-ones and Pyrazolo[4,3-d]pyrimidin-7(6H)-ones via Amination of sp3 C-H Bond

Shabber Mohammed, Ram A. Vishwakarma* and Sandip B. Bharate*

*Medicinal Chemistry Division and Academy of Scientific & Innovative Research, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India, Email:,

S. Mohammed, R. A. Vishwakarma, S. B. Bharate, J. Org. Chem., 2015, 80, 6915-6921.

DOI: 10.1021/acs.joc.5b00989

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Molecular iodine catalyzes a metal-free oxidative coupling of 2-aminobenzamides with aryl methyl ketones to yield 2-aryl quinazolin-4(3H)-ones. The selectivity of the reaction strongly depends on the quantity of iodine.

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Key Words

quinazolinones, oxygen

ID: J42-Y2015