Ligand Control of E/Z Selectivity in Nickel-Catalyzed Transfer Hydrogenative Alkyne Semireduction
Edward Richmond and Joseph Moran*
*ISIS & icFRC, Université de Strasbourg & CNRS, 8 allée Gaspard Monge, 67000 Strasbourg, France, Email: moranunistra.fr
E. Richmond, J. Moran, J. Org. Chem., 2015, 80, 6922-6929.
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Ni catalysis enables a transfer hydrogenative alkyne semireduction protocol that can be applied to both internal and terminal alkynes in the presence of formic acid and Zn as the terminal reductants. Both (E)- and (Z)-isomers can be accessed selectively under similar reaction conditions.
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