Synthesis of Isatins through Direct Oxidation of Indoles with IBX-SO3K/NaI
Angla Bredenkamp, Fabian Mohr, Stefan F. Kirsch*
*Organic Chemistry, Bergische Universität Wuppertal, Gaußstr.
20, 42119 Wuppertal, Germany, Email: sfkirsch
uni-wuppertal.de
A. Bredenkamp, F. Mohr, S. F. Kirsch, Synthesis, 2015, 47, 1937-1943.
DOI: 10.1055/s-0034-1380517
Abstract
The reagent mixture NaI/IBX-SO3K, containing a sulfonylated derivative of 2-iodoxybenzoic acid, was employed for an oxidative direct conversion of indoles into isatins. A synthetic route toward IBX-SO3K and the X-ray crystal structure of the reagent are presented.
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Key Words
IBX, oxidation, indoles, isatins, heterocycles
ID: J66-Y2015
