Synergistic Gold and Iron Dual Catalysis: Preferred Radical Addition toward Vinyl-Gold Intermediate over Alkene
Haihui Peng, Novruz G. Akhmedov, Yu-Feng Liang, Ning Jiao* and Xiaodong Shi*
*Peking University, Xue Yuan Road 38, Beijing 100191, China; West Virginia University, Morgantown, West Virginia 26506, United States, Email: Jiaoningbjmu.edu.cn, Xiaodong.Shimail.wvu.edu
H. Peng, N. G. Akhmedov, Y.-F. Liang, N. Jiao, X. Shi, J. Am. Chem. Soc., 2015, 137, 8912-8915.
DOI: 10.1021/jacs.5b05415 (free Supporting Information)
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A dual catalytic approach offers readily access to substituted heterocycle aldehydes via oxygen radical addition to vinyl-gold intermediates under Fe catalyst assistance. This system offers good functional group compatibility for the synthesis of substituted oxazole, indole, and benzofuran aldehydes.
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