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Domino One-Pot Process for the Synthesis of Isobenzofuran-1(3H)-ones via [Cu]-Catalysis Using Water as the Green Solvent

Lodi Mahendar and Gedu Satyanarayana*

*Department of Chemistry, Indian Institute of Technology Hyderabad, Ordnance Factory Estate Campus, Yeddumailaram-502 205, Medak District, Telangana, India, Email:

L. Mahendar, G. Satyanarayana, J. Org. Chem., 2015, 80, 7089-7098.

DOI: 10.1021/acs.joc.5b00888 (free Supporting Information)


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An efficient domino one-pot strategy for the synthesis of isobenzofuran-1(3H)-ones includes [Cu]-catalyzed intermolecular cyanation of o-bromobenzyl alcohols, in situ intramolecular nucleophilic attack and hydrolysis. This reaction can successfully be carried out under environmentally benign conditions, using water as sole green solvent.

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Domino [Pd]-Catalysis: One-Pot Synthesis of Isobenzofuran-1(3H)-ones

L. Mahendar, G. Satyanarayana, J. Org. Chem., 2016, 81, 7685-7691.

Key Words

phthalides, green chemistry

ID: J42-Y2015