Direct Access to N-Alkylsulfoximines from Sulfides by a Sequential Imidation/Oxidation Procedure
Carl Albrecht Dannenberg, Vincent Bizet, Carsten Bolm*
*Institute of Organic Chemistry, RWTH Aachen University,
Landoltweg 1, 52074 Aachen, Germany, Email: carsten.bolm
oc.rwth-aachen.de
C. A. Dannenberg, V. Bizet, C. Bolm, Synthesis, 2015, 47, 1951-1959.
DOI: 10.1055/s-0034-1380536
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Abstract
In a preparation of N-alkyl-substituted sulfoximines from sulfides, in situ generated N-bromoalkylamines serve as readily accessible imidating agents leading to N-alkylsulfiliminium bromides that are subsequently oxidized providing the desired products. This unprecedented one-pot imidation/oxidation sequence provides gram quantities of product in a short period of time avoiding the use of toxic alkylating reagents.
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Key Words
sulfoximines, oxidation, synthetic method, sulfide. potassium permanganate
ID: J66-Y2015
