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Copper-Catalyzed Synthesis of 2-Arylquinazolinones from 2-Arylindoles with Amines or Ammoniums

Yadong Feng, Yudong Li, Guolin Cheng, Lianhui Wang and Xiuling Cui*

*Institutes of Molecular Medicine and School of Biomedical Sciences, Huaqiao University & Engineering Research Center of Molecular Medicine, Ministry of Education, Xiamen 361021, China, Email:

Y. Feng, Y. Li, G. Cheng, L. Wang, X. Cui, J. Org. Chem., 2015, 80, 7099-7107.

DOI: 10.1021/acs.joc.5b00957

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A copper-catalyzed reaction of easily available 2-arylindoles and amines or ammonium provides various quinazolinones in very good yields in the presence of oxygen. This simple and mild reaction tolerates a broad range of functional groups.

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Key Words

quinazolinones, oxygen

ID: J42-Y2015