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I2/KI-Mediated Oxidative N-N Bond Formation for the Synthesis of 1,5-Fused 1,2,4-Triazoles from N-Aryl Amidines

Lina Song, Xianhai Tian, Zhigang Lv, Ertong Li, Jie Wu, Yangxue Liu, Wenquan Yu* and Junbiao Chang*

*College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, Henan 450001, P. R. China, Email:,

L. Song, X. Tian, Z. Lv, E. Li, J. Wu, Y. Liu, W. Yu, J. Chang, J. Org. Chem., 2015, 80, 7219-7225.

DOI: 10.1021/acs.joc.5b01183

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An I2/KI-mediated oxidative N-N bond formation reaction enables an environmentally benign synthesis of various 1,2,4-triazolo[1,5-a]pyridines and other 1,5-fused 1,2,4-triazoles from readily available N-aryl amidines in an efficient and scalable fashion.

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Key Words

1,2,4-triazolo[1,5-a]pyridines, iodine

ID: J42-Y2015