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Synthesis of 4-(Dimethylamino)quinazoline via Direct Amination of Quinazolin-4(3H)-one Using N,N-Dimethylformamide as a Nitrogen Source at Room Temperature

Xin Chen, Qin Yang, Yirong Zhou, Zhihong Deng, Xuechun Mao, Yiyuan Peng*

*Key Laboratory of Green Chemistry, Jiangxi Province College of Chemistry, Jiangxi Normal University, Nanchang, Jiangxi 330022, P. R. of China, Email: yypengjxnu.edu.cn

X. Chen, Q. Yang, Y. Zhou, Z. Deng, X. Mao, Y. Peng, Synthesis, 2015, 47, 2055-2062.

DOI: 10.1055/s-0034-1380550 (free Supporting Information)


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Abstract

An efficient direct amination of quinazolin-4(3H)-ones using N,N-dimethylformamide as a nitrogen source affords the corresponding 4-(dimethylamino)quinazolines in high yields via efficient 4-toluenesulfonyl chloride mediated C-OH bond activation at room temperature.


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Key Words

quinazolin-4(3H)-ones, 4-aminoquinazolines, quinazolines


ID: J66-Y2015