Organic Chemistry Portal



External Oxidant-Free Oxidative Cross-Coupling: A Photoredox Cobalt-Catalyzed Aromatic C-H Thiolation for Constructing C-S Bonds

Guoting Zhang, Chao Liu, Hong Yi, Qingyuan Meng, Changliang Bian, Hong Chen, Jing-Xin Jian, Li-Zhu Wu* and Aiwen Lei*

*Chinese Academy of Sciences, Beijing 100190; Wuhan University, Wuhan, Hubei 430072, P. R. China, Email:,

G. Zhang, C. Liu, H. Yi, Q. Meng, C. Bian, H. Chen, J.-X. Jian, L.-Z. Wu, A. Lei, J. Am. Chem. Soc., 2015, 137, 9273-9280.

DOI: 10.1021/jacs.5b05665

see article for more reactions


An external oxidant-free oxidative coupling for aromatic C-H thiolation using visible-light photoredox cobalt-catalysis affords benzothiazoles in good to excellent yields with only H2 as a side product. When catalytic TBAOH was used as the base, not only 2-aryl but also 2-alkylbenzothiazoles could be obtained.

see article for more examples

Key Words


ID: J48-Y2015